Upper limits of normal for alanine aminotransferase activity in the United States population
نویسندگان
چکیده
منابع مشابه
Upper Limits of Normal for Serum Alanine Aminotransferase Levels in Chinese Han Population
BACKGROUND AND OBJECTIVES Serum alanine aminotransferase (ALT) activity is the most common tool for the assessment of liver diseases. However, it is not clear whether the current normal ALT range really discriminate patients with or without liver diseases. The present study was to establish a new normal range of ALT and examine its ability to identify patients with hepatitis B or nonalcoholic f...
متن کاملUpper limit of normal for alanine aminotransferase: quo vadis?
Several studies suggest that a substantial number of patients with normal serum alanine aminotransferase (ALT) levels, defined by current thresholds, have ongoing hepatic necro-inflammation and fibrosis, and are at risk of liver disease progression. A major problem lies in the definition of normality. The current upper limit of normal (ULN) for ALT was established in the 1980s when reference po...
متن کاملElevated serum alanine aminotransferase and gamma-glutamyltransferase and mortality in the United States population.
BACKGROUND & AIMS Elevated serum alanine aminotransferase (ALT) and gamma-glutamyltransferase (GGT) activities are markers of liver injury, but may also be associated with other diseases and death. In a prospective, national, population-based sample, we examined whether elevated ALT and GGT were associated with increased risk of all-cause and disease-specific mortality. METHODS Death certific...
متن کاملRedefining the alanine aminotransferase upper limit of normal improves the prediction of metabolic syndrome risk.
BACKGROUND Multiple studies have recently proposed the lowering of upper limit of normal (ULN) for alanine aminotransferase (ALT) to improve the diagnostic sensitivity for viral hepatitides and metabolic syndrome (MS). We have tried to validate some of the proposed ULNs in the diagnosis of MS. METHODS We used data from the HepaMeta Study conducted in 2011 in Slovakia, which explored the preva...
متن کاملRe-evaluation of serum alanine aminotransferase upper normal limit and its modulating factors in a large-scale population study.
BACKGROUND The upper normal limit (ULN) of serum alanine-aminotrasferase (ALT) normal range was recently challenged, because patients diagnosed with liver diseases may have 'normal' or near-'normal' ALT levels, and because possible modulators are often ignored in determining normal range. AIM To estimate the ULN for serum ALT and to identify factors modulating it. SUBJECTS AND METHODS We re...
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ژورنال
عنوان ژورنال: Hepatology
سال: 2012
ISSN: 0270-9139
DOI: 10.1002/hep.24725